The player assumes the role of Ramiro "Ram" Cruz; criminal turned DEA Agent. He has been sent into the Mexican border city of Los Toros and its surroundings by his twin brother Tommy, who wants him to find out who killed their father Ernesto. The player will be tasked with infiltrating and taking down the biggest drug cartel in Mexico and battling it out with dope dealers, banditos, corrupt Federales and Mexican Army, loco luchadores, guerillas, and other assorted bad guys. Between story missions the player can do optional challenge missions as he or she wishes, exploring Los Toros and gathering bonuses to rack up a high score.
At the beginning, the player assumes the role as Ernesto Cruz, the boys' father. After Ernesto and the DEA attack the military in the jungle to take some info on Papa Muerte, Ernesto is thrown from the plane and killed. Colonel (Commander) Trust believes it's a drug overdose, however, Tommy suspects an agent. In second mission you are Tommy. Tommy meets Marco, who is his primary contact with Morales Cartel. Then Tommy destroys Virgillo gang convoy and their gas station, but is seriously wounded. His twin brother Ramiro takes the job. While searching who is responsible for his father's death, he will have to kill, befriend and interrogate many banditos, gangsters and drug dealers to get to the truth.